There is a proud history of winning on Palatine Hill. With the addition of championships in Men's Rowing and Men's Basketball in 2007, Lewis & Clark teams have won 104 total Conference Championships in 17 different sports. The Men's Track and Women's Volleyball have each won 14 titles throughout the years, with Men's Basketball right behind with 13.

In addition to team championships, individual athletes have also won championships for the Pioneers. In 2005, cross country runner Carla McHattie was the first-ever female Pioneer to win a Northwest Conference Cross Country Championship. The Pioneers have five times had the top male runner at the cross country championships, a feat twice accomplished by Chris Miller (1963, 1965) and current Pioneer coach David Fix (1967, 1968). In track, the Pioneer men have won 191 individual conference titles. The women have amassed 48 including 2007's javelin title won by Roxanne Gilbride.